Memory CD8 T-cell compartment grows in size with immunological experience

@article{Vezys2009MemoryCT,
  title={Memory CD8 T-cell compartment grows in size with immunological experience},
  author={Vaiva D Vezys and Andrew Yates and Kerry A Casey and Gibson Lanier and Rafi Ahmed and Rustom Antia and David Masopust},
  journal={Nature},
  year={2009},
  volume={457},
  pages={196-199}
}
Memory CD8 T cells, generated by natural pathogen exposure or intentional vaccination, protect the host against specific viral infections. It has long been proposed that the number of memory CD8 T cells in the host is inflexible, and that individual cells are constantly competing for limited space. Consequently, vaccines that introduce over-abundant quantities of memory CD8 T cells specific for an agent of interest could have catastrophic consequences for the host by displacing memory CD8 T… CONTINUE READING
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