Memory CD4+ T cells do not induce graft-versus-host disease.

  title={Memory CD4+ T cells do not induce graft-versus-host disease.},
  author={Britt E. Anderson and Jennifer Madison McNiff and Jun Yan and Hester A. Doyle and Mark J. Mamula and Mark J. Shlomchik and Warren D Shlomchik},
  journal={The Journal of clinical investigation},
  volume={112 1},
Graft-versus-host disease (GVHD) remains a major cause of morbidity and mortality in allogeneic stem cell transplantation (alloSCT). Donor T cells that accompany stem cell grafts cause GVHD by attacking recipient tissues; therefore, all patients receive GVHD prophylaxis by depletion of T cells from the allograft or through immunosuppressant drugs. In addition to providing a graft-versus-leukemia effect, donor T cells are critical for reconstituting T cell-mediated immunity. Ideally, immunity to… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 145 extracted citations


Publications referenced by this paper.
Showing 1-10 of 38 references

Similar Papers

Loading similar papers…