Memory CD4+ T cells do not induce graft-versus-host disease.

@article{Anderson2003MemoryCT,
  title={Memory CD4+ T cells do not induce graft-versus-host disease.},
  author={Britt E. Anderson and Jennifer Madison McNiff and Jun Yan and Hester A. Doyle and Mark J. Mamula and Mark J. Shlomchik and Warren D Shlomchik},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={112 1},
  pages={101-8}
}
Graft-versus-host disease (GVHD) remains a major cause of morbidity and mortality in allogeneic stem cell transplantation (alloSCT). Donor T cells that accompany stem cell grafts cause GVHD by attacking recipient tissues; therefore, all patients receive GVHD prophylaxis by depletion of T cells from the allograft or through immunosuppressant drugs. In addition to providing a graft-versus-leukemia effect, donor T cells are critical for reconstituting T cell-mediated immunity. Ideally, immunity to… CONTINUE READING

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