Memory CD4+ T-cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectors.

@article{Strutt2012MemoryCT,
  title={Memory CD4+ T-cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectors.},
  author={Tara M Strutt and Karl Kai McKinstry and Yi Kuang and Linda M Bradley and Susan L Swain},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 38},
  pages={E2551-60}
}
Whether differences between naive cell-derived primary (1°) and memory cell-derived secondary (2°) CD4(+) T-cell effectors contribute to protective recall responses is unclear. Here, we compare these effectors directly after influenza A virus infection. Both develop with similar kinetics, but 2° effectors accumulate in greater number in the infected lung and are the critical component of memory CD4(+) T-cell-mediated protection against influenza A virus, independent of earlier-acting memory… CONTINUE READING

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