Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection.

@article{Onodera2012MemoryBC,
  title={Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection.},
  author={Taishi Onodera and Yoshimasa Takahashi and Yusuke Yokoi and Manabu Ato and Yuichi Kodama and Satoshi Hachimura and Tomohiro Kurosaki and Kazuo Kobayashi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 7},
  pages={2485-90}
}
After pulmonary virus infection, virus-binding B cells ectopically accumulate in the lung. However, their contribution to protective immunity against reinfecting viruses remains unknown. Here, we show the phenotypes and protective functions of virus-binding memory B cells that persist in the lung following pulmonary infection with influenza virus. A fraction of virus-binding B-cell population in the lung expressed surface markers for splenic mature memory B cells (CD73, CD80, and CD273) along… CONTINUE READING
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