Memory--a century of consolidation.

  title={Memory--a century of consolidation.},
  author={J. D. McGaugh},
  volume={287 5451},
The memory consolidation hypothesis proposed 100 years ago by Müller and Pilzecker continues to guide memory research. The hypothesis that new memories consolidate slowly over time has stimulated studies revealing the hormonal and neural influences regulating memory consolidation, as well as molecular and cellular mechanisms. This review examines the progress made over the century in understanding the time-dependent processes that create our lasting memories. 

The Consolidation and Transformation of Memory

Commentary — reconsolidation: Memory traces revisited

The implications of these and earlier findings to the understanding of consolidation are commented on, and their possible relationship to the idea that retrieval creates a new memory trace, increasing the resistance of older memories to disruption is explored.

Molecular signatures and mechanisms of long-lasting memory consolidation and storage

Memory, Consolidation of

Molecular mechanisms of memory reconsolidation

Understanding the molecular mechanisms of reconsolidation could provide crucial insights into the dynamic aspects of normal mnemonic function and psychiatric disorders that are characterized by exceptionally strong and salient emotional memories.

Molecular stepping stones in memory consolidation

Antisense against the transcription factor C/EBPβ in the hippocampus is now reported to disrupt the initial consolidation of memories, but not their 'reconsolidation' after later recall.

Reply — reconsolidation: The labile nature of consolidation theory

It is argued that consolidation is not a one-time event, but instead is reiterated with subsequent activation of the memories, opening up a new dimension in the study of memory consolidation.

Consolidation and Reconsolidation: Two Lives of Memories?




Mechanisms for memory types differ

Four treatments that block short-term memory while leaving long- term memory intact are reported, showing that these memory systems are separate to some degree.

Memory: From Mind to Molecules

From mind to molecules studies of simple forms of nondeclarative memory show that memory is stored through alternations in synaptic strength molecules import for short-term memory declarative memory

Long-term potentiation--a decade of progress?

A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.

A post-tetanic time window for the reinforcement of long-term potentiation by appetitive and aversive stimuli.

LTP in the dentate gyrus of freely moving rats was reinforced after its induction by appetitive and aversive stimuli, and was blocked by the beta-adrenergic antagonist propranolol, implicating norepinephrine in the underlying cellular processes.

Time-Dependent Processes in Memory Storage

The findings indicate that the long-lasting trace of an experience is not completely fixed, consolidated, or coded at the time of the experience, and that any search for the engram or the basis of memory is not going to be successful.

Cognitive Neuroscience Analyses of Memory: A Historical Perspective

A historical review of three major issues in memory research---consolidation processes, the nature of memory representations, and multiple memory systems---is presented.

100 years of consolidation--remembering Müller and Pilzecker.

This commentary is intended to outline the experimental work of Müller and Pilzecker to explicate how the concept of memory consolidation originated.

Neural correlates of motor memory consolidation.

Functional imaging of the brain demonstrates that within 6 hours after completion of practice, while performance remains unchanged, the brain engages new regions to perform the task; there is a shift from prefrontal regions of the cortex to the premotor, posterior parietal, and cerebellar cortex structures, specific to recall of an established motor skill.

Tuning the brain by learning and by stimulation of the nucleus basalis