Memories from the polycomb group proteins.

  title={Memories from the polycomb group proteins.},
  author={Chiara Lanzuolo and Valerio Orlando},
  journal={Annual review of genetics},
The first genes composing the Polycomb group (PcG) were identified 50 years ago in Drosophila melanogaster as essential developmental functions that regulate the correct segmental expression of homeotic selector genes. In the past two decades, what was initially described as a large family of chromatin-associated proteins involved in the maintenance of transcriptional repression to maintain cellular memory of homeotic genes turned out to be a highly conserved and sophisticated network of… CONTINUE READING
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