Memo is a cofilin-interacting protein that influences PLCgamma1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration.

@article{Meira2009MemoIA,
  title={Memo is a cofilin-interacting protein that influences PLCgamma1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration.},
  author={Maria Isis Marinho Meira and R{\'e}gis Masson and Igor Stagljar and Susanne Lienhard and Francisca G. Maurer and Anne Boulay and Nancy E. Hynes},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 6},
  pages={787-97}
}
Heregulin (HRG) activates ErbB2-ErbB3 heterodimers thereby stimulating many cellular responses, including motility. Memo and PLCgamma1 interact with ErbB2 autophosphorylation sites and are essential for HRG-induced chemotaxis. By tracing HRG-stimulated cell migration in Dunn chambers, we found that Memo- or PLCgamma1 knockdown (KD) strongly impairs cell directionality. Memo has no obvious enzymatic activity and was discovered via its ability to complex with ErbB2. Using the yeast two-hybrid… CONTINUE READING