Memo Is a Copper-Dependent Redox Protein with an Essential Role in Migration and Metastasis

  title={Memo Is a Copper-Dependent Redox Protein with an Essential Role in Migration and Metastasis},
  author={Gwen Macdonald and Ivan Nalvarte and Tatiana Smirnova and Manuela Vecchi and Nicola Aceto and Arno Doelemeyer and Anna Frei and Susanne Lienhard and Jeffrey B. Wyckoff and Daniel Hess and Jan Seebacher and Jeremy J. Keusch and Heinz Gut and Dani{\`e}le Salaun and Giovanni M Mazzarol and Davide Disalvatore and Mohamed Bentires-Alj and Pier Paolo Di Fiore and Ali Badache and Nancy E. Hynes},
  journal={Science Signaling},
Memo is an evolutionarily conserved protein with a critical role in cell motility. We found that Memo was required for migration and invasion of breast cancer cells in vitro and spontaneous lung metastasis from breast cancer cell xenografts in vivo. Biochemical assays revealed that Memo is a copper-dependent redox enzyme that promoted a more oxidized intracellular milieu and stimulated the production of reactive oxygen species (ROS) in cellular structures involved in migration. Memo was also… CONTINUE READING
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