Membranous nephropathy: from models to man.

  title={Membranous nephropathy: from models to man.},
  author={Laurence H. Beck and David J Salant},
  journal={The Journal of clinical investigation},
  volume={124 6},
As recently as 2002, most cases of primary membranous nephropathy (MN), a relatively common cause of nephrotic syndrome in adults, were considered idiopathic. We now recognize that MN is an organ-specific autoimmune disease in which circulating autoantibodies bind to an intrinsic antigen on glomerular podocytes and form deposits of immune complexes in situ in the glomerular capillary walls. Here we define the clinical and pathological features of MN and describe the experimental models that… CONTINUE READING
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Publications referenced by this paper.
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Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.

The New England journal of medicine • 2011
View 5 Excerpts
Highly Influenced

Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy

E Hoxha
Kidney Int • 2012
View 4 Excerpts
Highly Influenced

Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies.

The New England journal of medicine • 2002
View 6 Excerpts
Highly Influenced

Differential diagnosis of membranous nephropathy with autoantibodies to phospholipase A2 receptor

W Schlumberger
Autoimmun Rev • 2014
View 1 Excerpt

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