Membranous nephropathy: from models to man.

@article{Beck2014MembranousNF,
  title={Membranous nephropathy: from models to man.},
  author={Laurence H. Beck and David J Salant},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 6},
  pages={2307-14}
}
As recently as 2002, most cases of primary membranous nephropathy (MN), a relatively common cause of nephrotic syndrome in adults, were considered idiopathic. We now recognize that MN is an organ-specific autoimmune disease in which circulating autoantibodies bind to an intrinsic antigen on glomerular podocytes and form deposits of immune complexes in situ in the glomerular capillary walls. Here we define the clinical and pathological features of MN and describe the experimental models that… CONTINUE READING
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