Membranous expression of ectodomain isoforms of the epidermal growth factor receptor predicts outcome after chemoradiotherapy of lymph node-negative cervical cancer.

@article{Halle2011MembranousEO,
  title={Membranous expression of ectodomain isoforms of the epidermal growth factor receptor predicts outcome after chemoradiotherapy of lymph node-negative cervical cancer.},
  author={Cathinka Halle and Malin Lando and Debbie Hege Svendsrud and Trevor Clancy and Marit Holden and Kolbein Sundf\or and Gunnar Balle Kristensen and Ruth Holm and Heidi Lyng},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2011},
  volume={17 16},
  pages={5501-12}
}
PURPOSE We compared the prognostic significance of ectodomain isoforms of the epidermal growth factor receptor (EGFR), which lack the tyrosine kinase (TK) domain, with that of the full-length receptor and its autophosphorylation status in cervical cancers treated with conventional chemoradiotherapy. EXPERIMENTAL DESIGN Expression of EGFR isoforms was assessed by immunohistochemistry in a prospectively collected cohort of 178 patients with squamous cell cervical carcinoma, and their detection… CONTINUE READING