Membranoproliferative glomerulonephritis associated with a mutation in Wilms’ tumour suppressor gene 1

@article{Bockenhauer2009MembranoproliferativeGA,
  title={Membranoproliferative glomerulonephritis associated with a mutation in Wilms’ tumour suppressor gene 1},
  author={Detlef Bockenhauer and William G. van’t Hoff and Gil Chernin and Saskia F. Heeringa and Neil J Sebire},
  journal={Pediatric Nephrology},
  year={2009},
  volume={24},
  pages={1399-1401}
}
Wilms’ tumour suppressor gene 1 (WT1) encodes a transcription factor required for normal development of the genitourinary system. In the kidney, mutations in WT1 can cause diffuse mesangial sclerosis or focal segmental glomerulosclerosis. Here, we report on a girl with a mutation in WT1, who developed membranoproliferative glomerulonephritis (MPGN) 3 years after completion of treatment for Wilms’ tumour. This finding extends the spectrum of glomerular disease seen with WT1 mutations and could… CONTINUE READING
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WT1 and glomerular diseases

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