Membranoproliferative glomerulonephritis and mixed cryoglobulinemia after hepatitis C virus infection secondary to glomerular NS3 viral antigen deposits.

@article{Bataille2012MembranoproliferativeGA,
  title={Membranoproliferative glomerulonephritis and mixed cryoglobulinemia after hepatitis C virus infection secondary to glomerular NS3 viral antigen deposits.},
  author={Stanislas Bataille and Gilles Kaplanski and Jos{\'e} Boucraut and Philippe Halfon and Claire Camus and Laurent Daniel and St{\'e}phane Burtey and Yvon Berland and Bertrand M. Dussol},
  journal={American journal of nephrology},
  year={2012},
  volume={35 2},
  pages={
          134-40
        }
}
BACKGROUND We report on 3 cases of membranoproliferative glomerulonephritis associated with mixed cryoglobulin in patients with hepatitis C virus (HCV) antibodies but a negative blood viral load. These cases explore the pathogenesis of the renal disease. METHODS We searched for occult HCV infection in peripheral blood mononuclear cells, cryoprecipitate, bone marrow cells, and glomeruli using ultrasensitive PCR assays and immunohistochemistry. We also looked for infraclinical B cell lymphoma… CONTINUE READING
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