Membranes, ions, and clocks: testing the Njus-Sulzman-Hastings model of the circadian oscillator.

@article{Nitabach2005MembranesIA,
  title={Membranes, ions, and clocks: testing the Njus-Sulzman-Hastings model of the circadian oscillator.},
  author={Michael N. Nitabach and Todd C Holmes and Justin Blau},
  journal={Methods in enzymology},
  year={2005},
  volume={393},
  pages={682-93}
}
Current circadian clock models based on interlocking autoregulatory transcriptional?translational negative feedback loops have arisen out of an explosion of molecular genetic data obtained over the last decade (for review, see Stanewsky, 2003; Young and Kay, 2001). An earlier model of circadian oscillation was based on feedback interactions between membrane ion transport systems and ion concentration gradients (Njus et al., 1974, 1976). This membrane model was posited as a more plausible… CONTINUE READING