Membrane-type matrix metalloproteinase-9 activity in placental tissue from patients with pre-existing and gestational diabetes mellitus.

@article{Pustovrh2000MembranetypeMM,
  title={Membrane-type matrix metalloproteinase-9 activity in placental tissue from patients with pre-existing and gestational diabetes mellitus.},
  author={Carolina Pustovrh and Alicia Jawerbaum and D{\'e}bora Sinner and Marzia Pesaresi and Mario Baier and Paula Micone and Martha F. de Gimeno and Elida Gonz{\'a}lez},
  journal={Reproduction, fertility, and development},
  year={2000},
  volume={12 5-6},
  pages={
          269-75
        }
}
The activity of matrix metalloproteinase (MMP)-9 was evaluated in placental tissue from healthy subjects (controls) and from patients with gestational and pre-existing diabetes mellitus (GDM and PDM, respectively). Compared with controls, MMP-9 activity was greater in placental tissue from patients with PDM and lower in placental tissue from patients with GDM. The modulatory role of nitric oxide (NO) and reactive oxygen species (ROS) on MMP-9 activity in placental tissue was evaluated. In… CONTINUE READING
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