Membrane-type matrix metalloproteinase-1(MT1-MTP) gene is overexpressed in highly invasive hepatocellular carcinomas.

@article{Harada1998MembranetypeMM,
  title={Membrane-type matrix metalloproteinase-1(MT1-MTP) gene is overexpressed in highly invasive hepatocellular carcinomas.},
  author={Tadashi Harada and Shigeki Arii and Masahiro Mise and Takahisa Imamura and Hiroaki Higashitsuji and Masanori Furutani and Mototaka Niwano and Sumiya Ishigami and Manabu Fukumoto and Motoharu Seiki and Hiroshi Sato and Masayuki Imamura},
  journal={Journal of hepatology},
  year={1998},
  volume={28 2},
  pages={231-9}
}
BACKGROUND/AIMS The matrix metalloproteinase (MMP) family play important roles in the invasion of cancer cells by degrading the extracellular matrices. The current study was designed to determine the expression pattern of membrane-type matrix metalloproteinase-1 (MT1-MMP) in hepatocellular carcinomas and its participation in invasion potential. METHODS MT1-MMP mRNA expression was examined in 25 human hepatocellular carcinoma specimens using Northern blot, and the correlation to… CONTINUE READING