Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules.

Abstract

Membrane type 1 matrix metalloproteinase (MT1-MMP) is expressed on cancer cell membranes and activates the zymogen of MMP-2 (gelatinase A). We have recently isolated MT1-MMP complexed with tissue inhibitor of metalloproteinases 2 (TIMP-2) and demonstrated that MT1-MMP exhibits gelatinolytic activity by gelatin zymography (Imai, K., Ohuchi, E., Aoki, T… (More)

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Cite this paper

@article{Ohuchi1997MembraneT1, title={Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules.}, author={Eiko Ohuchi and K. Imai and Yukihiko Fujii and H. Sato and Motoharu Seiki and Y. Okada}, journal={The Journal of biological chemistry}, year={1997}, volume={272 4}, pages={2446-51} }