Membrane type-1 matrix metalloproteinase potentiates basic fibroblast growth factor-induced corneal neovascularization.

@article{Onguchi2009MembraneTM,
  title={Membrane type-1 matrix metalloproteinase potentiates basic fibroblast growth factor-induced corneal neovascularization.},
  author={Tatsuya Onguchi and Kyu Yeon Han and Jin-Hong Chang and Dimitri T. Azar},
  journal={The American journal of pathology},
  year={2009},
  volume={174 4},
  pages={1564-71}
}
Corneal neovascularization is one of the leading causes of blindness. The aim of this study was to evaluate the pro-angiogenic role of corneal fibroblast-derived membrane type-1 matrix metalloproteinase (MT1-MMP) on basic fibroblast growth factor (bFGF)-induced corneal neovascularization in vivo and in vitro. Immunohistochemical studies demonstrated that… CONTINUE READING