Membrane transport of hydrocortisone acetate from supersaturated solutions; the role of polymers.

@article{Raghavan2001MembraneTO,
  title={Membrane transport of hydrocortisone acetate from supersaturated solutions; the role of polymers.},
  author={Suraj Raghavan and B Kiepfer and Anson F Davis and Sergei G. Kazarian and Jonathan Hadgraft},
  journal={International journal of pharmaceutics},
  year={2001},
  volume={221 1-2},
  pages={95-105}
}
Permeation of hydrocortisone acetate (HA) from supersaturated solutions was studied across a model silicone membrane. Supersaturated solutions were prepared using the cosolvent technique with propylene glycol and water (or aqueous polymer solutions) as the cosolvents. In the absence of the polymer, the flux of HA was similar at all degrees of saturation and was not significantly different from the value obtained for a saturated solution. Flux enhancement, as a result of supersaturation, was… CONTINUE READING