Membrane transport mechanisms probed by capacitance measurements with megahertz voltage clamp.

  title={Membrane transport mechanisms probed by capacitance measurements with megahertz voltage clamp.},
  author={C C Lu and Alexander E Kabakov and Vladislav S. Markin and Sela Mager and Gary A Frazier and Donald W Hilgemann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={92 24},
We have used capacitance measurements with a 1-microsecond voltage clamp technique to probe electrogenic ion-transporter interactions in giant excised membrane patches. The hydrophobic ion dipicrylamine was used to test model predictions for a simple charge-moving reaction. The voltage and frequency dependencies of the apparent dipicrylamine-induced capacitance, monitored by 1-mV sinusoidal perturbations, correspond to single charges moving across 76% of the membrane field at a rate of 9500 s-1… CONTINUE READING
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