Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3

@article{Gao2005MembraneTA,
  title={Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3},
  author={S. Gao and Wenting Fu and Markus D{\"u}rrenberger and Christian Geyter and H. Zhang},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2005},
  volume={62},
  pages={1015-1024}
}
hBok is a human pro-apoptotic member of the Bcl-2 family. By fluorescence in situ hybridization and in silico analysis, hBok was found to be located on chromosome 2q37.3. Its expression was detected in various organs and several hormonally regulated cancer cells. Expression of hBok was shown to be upregulated in estrogen-dependent breast cancer by estrogen deprivation and in myocardial cells during hypoxia. Confocal laser scanning microscopy examinations and subcellular fractionation studies… CONTINUE READING