Membrane-trafficking sorting hubs: cooperation between PI4P and small GTPases at the trans-Golgi network.

@article{SantiagoTirado2011MembranetraffickingSH,
  title={Membrane-trafficking sorting hubs: cooperation between PI4P and small GTPases at the trans-Golgi network.},
  author={Felipe H. Santiago-Tirado and Anthony Bretscher},
  journal={Trends in cell biology},
  year={2011},
  volume={21 9},
  pages={515-25}
}
Cell polarity in eukaryotes requires constant sorting, packaging and transport of membrane-bound cargo within the cell. These processes occur in two sorting hubs: the recycling endosome for incoming material and the trans-Golgi network for outgoing material. Phosphatidylinositol 3-phosphate and phosphatidylinositol 4-phosphate are enriched at the endocytic and exocytic sorting hubs, respectively, where they act together with small GTPases to recruit factors to segregate cargo and regulate… CONTINUE READING