Membrane topology of the human seipin protein.

  title={Membrane topology of the human seipin protein.},
  author={Carolina Lundin and Rickard Nordstr{\"o}m and Klaus Wagner and Christian Windpassinger and Helena Andersson and Gunnar von Heijne and Ingmarie Nilsson},
  journal={FEBS letters},
  volume={580 9},
The Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) gene encodes an integral membrane protein, called seipin, of unknown function localized to the endoplasmic reticulum of eukaryotic cells. Seipin is associated with the heterogeneous genetic disease BSCL2, and mutations in an N-glycosylation motif links the protein to two other disorders, autosomal-dominant distal hereditary motor neuropathy type V and Silver syndrome. Here, we report a topological study of seipin using an in vitro… CONTINUE READING
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