Membrane topology of human ABC proteins.

  title={Membrane topology of human ABC proteins.},
  author={G{\'a}bor E. Tusn{\'a}dy and Bal{\'a}zs Sarkadi and Istv{\'a}n Simon and Andr{\'a}s V{\'a}radi},
  journal={FEBS letters},
  volume={580 4},
In this review, we summarize the currently available information on the membrane topology of some key members of the human ABC protein subfamilies, and present the predicted domain arrangements. In the lack of high-resolution structures for eukaryotic ABC transporters this topology is based only on prediction algorithms and biochemical data for the location of various segments of the polypeptide chain, relative to the membrane. We suggest that topology models generated by the available… CONTINUE READING

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