Membrane topology of NS2B of dengue virus revealed by NMR spectroscopy.

  title={Membrane topology of NS2B of dengue virus revealed by NMR spectroscopy.},
  author={Yan Li and Qingxin Li and Ying Lei Wong and Lynette Sin Yee Liew and CongBao Kang},
  journal={Biochimica et biophysica acta},
  volume={1848 10 Pt A},
Non-structural (NS) proteins of dengue virus (DENV) are important for viral replication. There are four membrane proteins that are coded by viral genome. NS2B was shown to be one of the membrane proteins and its main function was confirmed to regulate viral protease activity. Its membrane topology is still not known because only few studies have been conducted to understand its structure. Here we report the determination of membrane topology of NS2B from DENV serotype 4 using NMR spectroscopy… CONTINUE READING
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