Membrane thinning effect of the beta-sheet antimicrobial protegrin.

  title={Membrane thinning effect of the beta-sheet antimicrobial protegrin.},
  author={William T. Heller and Alan J. Waring and Robert I. Lehrer and Thad A Harroun and Thomas M. Weiss and Lin Yang and Huey W Huang},
  volume={39 1},
Lipid bilayers containing the antimicrobial peptide protegrin-1 (PG-1) were studied by lamellar X-ray diffraction. Previously, we have shown that the peptide exists in two distinct states when associated with lipid bilayers depending on the peptide concentration [Heller, W. T., Waring, A. J., Lehrer, R. I., and Huang, H. W. (1998) Biochemistry 37, 17331-17338]. For concentrations below a lipid-dependent threshold, PG-1 exhibits a unique oriented circular dichroism spectrum called the S state. X… CONTINUE READING