Membrane tension homeostasis of epithelial cells through surface area regulation in response to osmotic stress.

@article{Pietuch2013MembraneTH,
  title={Membrane tension homeostasis of epithelial cells through surface area regulation in response to osmotic stress.},
  author={Anna Pietuch and Bastian Rouven Br{\"u}ckner and Andreas Janshoff},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1833 3},
  pages={
          712-22
        }
}
Osmotic stress poses one of the most fundamental challenges to living cells. Particularly, the largely inextensible plasma membrane of eukaryotic cells easily ruptures under in-plane tension calling for sophisticated strategies to readily respond to osmotic stress. We describe how epithelial cells react and adapt mechanically to the exposure to hypotonic and hypertonic solutions in the context of a confluent monolayer. Site-specific indentation experiments in conjunction with tether pulling on… CONTINUE READING

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