Membrane tension feedback on shape and motility of eukaryotic cells
@article{Winkler2015MembraneTF, title={Membrane tension feedback on shape and motility of eukaryotic cells}, author={Benjamin Winkler and Igor. S. Aranson and Falko Ziebert}, journal={Physica D: Nonlinear Phenomena}, year={2015}, volume={318}, pages={26-33} }
18 Citations
Modeling the mechanosensitivity of fast-crawling cells on cyclically stretched substrates.
- BiologySoft matter
- 2019
A computational model for fast crawling cells on cyclically stretched substrates that accounts for the sub-cellular elements responsible for cell shape and motility and shows that an asymmetry in the adhesion dynamics during the loading and unloading phases of the stretching, whether it comes from the response of the cell itself or from the precise stretching protocol, can be used to selectively align the cells.
Membrane tension can enhance adaptation to maintain polarity of migrating cells
- BiologybioRxiv
- 2020
A model of mechanochemical-based adaptation coupling a mechanics-based physical model of cell tension coupled with the wave-pinning reaction-diffusion model for Rac activity demonstrates how tension related mechanosensing may provide an alternative (and potentially complementary) mechanism for cell adaptation.
Computational approaches to substrate-based cell motility
- Biology
- 2016
The most recent advances in computational approaches to cell movement are surveyed and how these models improve the understanding of complex self-organised systems such as living cells are demonstrated.
Confinement and substrate topography control cell migration in a 3D computational model
- BiologyCommunications Physics
- 2019
A physics-driven three-dimensional computational modeling framework that describes lamellipodium-based motion of cells in arbitrarily shaped and topographically structured surroundings and finds that confinement, substrate curvature and topography modulate the cell’s speed, shape and actin organization and can induce changes in the direction of motion along axes defined by the constraints.
Reversible elastic phase field approach and application to cell monolayers
- BiologyThe European Physical Journal E
- 2020
An elastic phase field approach is introduced that allows us to predict the dynamics of elastic sheets under the action of active stresses and localized forces, e.g. from leader cells, and ensures elastic reversibility after release of forces.
The crucial role of adhesion in the transmigration of active droplets through interstitial orifices
- History
- 2022
Active fluid droplets are a class of soft materials exhibiting autonomous motion sustained by an energy supply. Such systems have been shown to capture motility regimes typical of biological cells and…
Phase-Field Modeling of Individual and Collective Cell Migration
- BiologyArchives of Computational Methods in Engineering
- 2019
A numerical implementation, based on isogeometric analysis, is described, which successfully deals with the challenges associated with phase-field problems and presents numerical simulations that illustrate the unique capabilities of the phase- field approach for cell migration.
Spontaneous polarization and cell guidance on asymmetric nanotopography
- BiologybioRxiv
- 2021
A three-dimensional model is used to demonstrate that nanosawteeth induce actin-mediated migration directionality, which is dependent on the cell velocity, and predicts that asymmetric sawteeth lead to spontaneous motion.
Directional and velocity control of active droplets using a rigid-frame
- Engineering, PhysicsRSC advances
- 2019
This paper introduces a novel directional control method of self-propelled oil droplets. Oil droplets locomote spontaneously with surfactant action. This self-propulsion is caused by Marangoni…
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