Membrane tension, myosin force, and actin turnover maintain actin treadmill in the nerve growth cone.

@article{Craig2012MembraneTM,
  title={Membrane tension, myosin force, and actin turnover maintain actin treadmill in the nerve growth cone.},
  author={Erin M Craig and David Van Goor and Paul Forscher and Alex Mogilner},
  journal={Biophysical journal},
  year={2012},
  volume={102 7},
  pages={1503-13}
}
A growth cone is a motile structure at the tips of axons that is driven by the actin network and guides axon extension. Low actin adhesion to the substrate creates a stationary actin treadmill that allows leading-edge protrusion when adhesion increases in response to guidance cues. We use experimental measurements in the Aplysia bag growth cone to develop and constrain a simple mechanical model of the actin treadmill. We show that actin retrograde flow is primarily generated by myosin… CONTINUE READING
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