Membrane structure modulation, protein kinase C alpha activation, and anticancer activity of minerval.

@article{Martnez2005MembraneSM,
  title={Membrane structure modulation, protein kinase C alpha activation, and anticancer activity of minerval.},
  author={Jordi Serrats Mart{\'i}nez and Oliver V{\"o}gler and Josefina Casas and Francisca Barcel{\'o} and Regina Alemany and Jes{\'u}s Prades and T{\"u}nde Nagy and Carmela Baamonde and Philip G. Kasprzyk and Silvia Ter{\'e}s and Carlos Saus and Pablo V. Escrib{\'a}},
  journal={Molecular pharmacology},
  year={2005},
  volume={67 2},
  pages={
          531-40
        }
}
Most drugs currently used for human therapy interact with proteins, altering their activity to modulate the pathological cell physiology. In contrast, 2-hydroxy-9-cis-octadecenoic acid (Minerval) was designed to modify the lipid organization of the membrane. Its structure was deduced following the guidelines of the mechanism of action previously proposed by us for certain antitumor drugs. The antiproliferative activity of Minerval supports the above-mentioned hypothesis. This molecule augments… CONTINUE READING
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