Membrane-stabilizing, anti-inflammatory interactions of macrolides with human neutrophils

@article{Anderson1996MembranestabilizingAI,
  title={Membrane-stabilizing, anti-inflammatory interactions of macrolides with human neutrophils},
  author={Ronald T. Anderson and Annette Theron and Charles Feldman},
  journal={Inflammation},
  year={1996},
  volume={20},
  pages={693-705}
}
The effects of the macrolide antimicrobial agents azithromycin, clarithromycin, erythromycin and roxithromycin on the prooxidative activity of stimulated human neutrophils have been investigated in vitro. Superoxide generation by activated neutrophils was measured by lucigenin-enhanced chemiluminescence. At the concentrations used (2.5–80 μg/ml) none of the test agents was cytotoxic, nor did they possess superoxide-scavenging properties. Treatment of neutrophils with all 4 macrolides was… CONTINUE READING

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