Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.

@article{Triantafilou2006MembraneSO,
  title={Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.},
  author={Martha Triantafilou and Frederick G J Gamper and Rowenna Mitch Haston and Marios Angelos Mouratis and Siegfried Morath and Thomas Hartung and Kathy Triantafilou},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 41},
  pages={
          31002-11
        }
}
Toll-like receptors (TLRs) are receptors of the innate immune system responsible for recognizing pathogen-associated molecular patterns. TLR2 seems to be the most promiscuous TLR receptor able to recognize the most diverse set of pathogen-associated patterns. Its promiscuity has been attributed to its unique ability to heterodimerize with TLRs 1 and 6 and, most recently, to its association with CD36 in response to diacylated lipoproteins. Thus, it seems that TLR2 forms receptor clusters in… CONTINUE READING
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