Membrane requirements for uridylylation of the poliovirus VPg protein and viral RNA synthesis in vitro.

@article{Fogg2003MembraneRF,
  title={Membrane requirements for uridylylation of the poliovirus VPg protein and viral RNA synthesis in vitro.},
  author={Mark H. Fogg and Natalya L. Teterina and Ellie Ehrenfeld},
  journal={Journal of virology},
  year={2003},
  volume={77 21},
  pages={11408-16}
}
Efficient translation of poliovirus (PV) RNA in uninfected HeLa cell extracts generates all of the viral proteins required to carry out viral RNA replication and encapsidation and to produce infectious virus in vitro. In infected cells, viral RNA replication occurs in ribonucleoprotein complexes associated with clusters of vesicles that are formed from preexisting intracellular organelles, which serve as a scaffold for the viral RNA replication complex. In this study, we have examined the role… CONTINUE READING
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