Membrane receptors.

  title={Membrane receptors.},
  author={Pedro Cuatrecasas},
  journal={Annual review of biochemistry},
  volume={43 0},
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Membrane receptors for hormones and neurotransmitters

  • C. Kahn
  • Biology, Chemistry
    The Journal of cell biology
  • 1976
Investigation of the hormone- receptor interaction will no doubt yield new insights into both the mechanism of hormone action and membrane structure and function.

Receptors and Recognition

The heterobifunctional reagents, which attach initially by normal chemical modification, and secondarily by photolysis of an appropriate group, are particularly useful for identifying ligand-binding components in complex biological systems.

Insulin binding to target cells

A new approach to the problem of ‘insulin resistance’ in obesity has been proposed, and this has shown that a reduction in the number of receptors on the target cells may contribute to peripheral insulin insensitivity.

Radioreceptor assays: plasma membrane receptors and assays for polypeptide and glycoprotein hormones.

  • D. Schulster
  • Biology, Medicine
    Journal of reproduction and fertility
  • 1977
Receptors for peptide, protein and glycoprotein hormones, and the catecholamines are located on the plasma membranes of their target cells. Preparations of the receptors may be used as specific,

Biological Membranes and Malignancy:

The current status and future prospects of developing anticancer agents that exploit molecular differences in membrane structure between normal and neoplastic cells are addressed.

Opiate Receptors and Their Clinical Implications

It is shown that for opiates to elicit their pharmacological effects on both the peripheral and central nervous system, there is a specialized site on the cell which is called the receptor and that occupation by an agonist elicits a response.


This review will be confined to the outer cell membrane (plasma unit membrane) and its significance in cell growth and its role in oncology and immunology.

Physical Characteristics of Insulin Receptors on Renal Cell Membranes

125I-insulin degradation occurred as a function of total insulin concentration in the kidney membrane system and reduced the amount of “bindable” free hormone.

G-protein-effector coupling: a real-time light-scattering assay for transducin-phosphodiesterase interaction.

The previous overall light-scattering (turbidity) approach was improved by a specific optical setup and millisecond time resolution which allowed isolation of a fast "PDE signal" which monitors Gt-PDE interaction on the membrane and in real time.

Dynamics in the plasma membrane: how to combine fluidity and order

The basic concepts of Brownian diffusion and lipid domain formation in model membranes are summarized and the development of ideas and tools in this field are tracked, outlining key results obtained on the dynamic processes at work in membrane structure and assembly.