Membrane receptor mapping: the membrane topography of Fc(epsilon)RI signaling.

@article{Oliver2004MembraneRM,
  title={Membrane receptor mapping: the membrane topography of Fc(epsilon)RI signaling.},
  author={Janet M. Oliver and Janet R. Pfeiffer and Zurab Surviladze and Stanly L. Steinberg and Karin Leiderman and Margaret L Sanders and Carla Wofsy and Jun Zhang and Hongyou Fan and Nicholas Andrews and Scott D. Bunge and Timothy J. Boyle and Paul G. Kotula and Bridget S. Wilson},
  journal={Sub-cellular biochemistry},
  year={2004},
  volume={37},
  pages={3-34}
}
Ligand binding to membrane receptors initiates cascades of biochemical events leading to physiological responses. Hundreds of proteins and lipids are implicated in signaling networks and programs in genomics and proteomics are continuously adding new components to the signaling "parts lists". Here, we generate high resolution maps of signaling networks using cytoplasmic face-up membrane sheets that can be labeled with immunogold probes (3-10 nm) and imaged in the transmission electron… CONTINUE READING

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