Membrane raft microdomains in chemokine receptor function.

  title={Membrane raft microdomains in chemokine receptor function.},
  author={Santos Ma{\~n}es and Rosa Ana Lacalle and Concepci{\'o}n G{\'o}mez-Mout{\'o}n and Gustavo del Real and Emilia Mira and Carlos Mart{\'i}nez-A},
  journal={Seminars in immunology},
  volume={13 2},
Cell chemotaxis requires the acquisition and maintenance of both spatial and functional asymmetry between initially equivalent cell parts. In leukocytes one becomes the leading edge and the other, the rear edge or uropod. The acquisition of this cell polarity is controlled by an array of chemoattractants, including those of the chemokine family. We propose that chemokine receptor activation in highly organized lipid raft domains is a major determinant for the correct localization of the… CONTINUE READING