Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis.

@article{Wilkinson2008MembraneRA,
  title={Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis.},
  author={D Katie Wilkinson and Esther J Turner and Edward T. Parkin and Ashley E Garner and Penny J Harrison and Mark S. Crawford and Gordon W. Stewart and Nigel M Hooper},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1778 1},
  pages={125-32}
}
In overhydrated hereditary stomatocytosis (OHSt), the membrane raft-associated stomatin is deficient from the erythrocyte membrane. We have investigated two aspects of raft structure and function in OHSt erythrocytes. First, we have studied the distribution of other membrane and cytoskeletal proteins in rafts by analysis of detergent-resistant membranes (DRMs). In normal erythrocytes, 29% of the actin was DRM-associated, whereas in two unrelated OHSt patients the DRM-associated actin was… CONTINUE READING

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