Membrane proteins as 14-3-3 clients in functional regulation and intracellular transport.

@article{Smith2011MembranePA,
  title={Membrane proteins as 14-3-3 clients in functional regulation and intracellular transport.},
  author={Andrew J. H. Smith and J{\"u}rgen Daut and Blanche Schwappach},
  journal={Physiology},
  year={2011},
  volume={26 3},
  pages={181-91}
}
14-3-3 proteins regulate the function and subcellular sorting of membrane proteins. Often, 14-3-3 binding to client proteins requires phosphorylation of the client, but the relevant kinase is unknown in most cases. We summarize current progress in identifying kinases that target membrane proteins with 14-3-3 binding sites and discuss the molecular… CONTINUE READING