Membrane protein insertion and assembly by the bacterial holo-translocon SecYEG–SecDF–YajC–YidC

@inproceedings{Komar2016MembranePI,
  title={Membrane protein insertion and assembly by the bacterial holo-translocon SecYEG–SecDF–YajC–YidC},
  author={Joanna Komar and Sara Alvira and Ryan J. Schulze and R{\'e}my Martin and Jelger A. Lycklama a Nijeholt and Sarah C. Lee and Tim R. Dafforn and Gabriele Deckers-Hebestreit and Imre Berger and Christiane Schaffitzel and Ian Collinson},
  booktitle={The Biochemical journal},
  year={2016}
}
Protein secretion and membrane insertion occur through the ubiquitous Sec machinery. In this system, insertion involves the targeting of translating ribosomes via the signal recognition particle and its cognate receptor to the SecY (bacteria and archaea)/Sec61 (eukaryotes) translocon. A common mechanism then guides nascent transmembrane helices (TMHs) through the Sec complex, mediated by associated membrane insertion factors. In bacteria, the membrane protein 'insertase' YidC ushers TMHs… CONTINUE READING
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