Membrane prostaglandin E synthase-1: a novel therapeutic target.

  title={Membrane prostaglandin E synthase-1: a novel therapeutic target.},
  author={Bengt Samuelsson and Ralf Morgenstern and P. -J. Jakobsson},
  journal={Pharmacological reviews},
  volume={59 3},
Prostaglandin E(2) (PGE(2)) is the most abundant prostaglandin in the human body. It has a large number of biological actions that it exerts via four types of receptors, EP1-4. PGE(2) is formed from arachidonic acid by cyclooxygenase (COX-1 and COX-2)-catalyzed formation of prostaglandin H(2) (PGH(2)) and further transformation by PGE synthases. The isomerization of the endoperoxide PGH(2) to PGE(2) is catalyzed by three different PGE synthases, viz. cytosolic PGE synthase (cPGES) and two… CONTINUE READING
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