Membrane properties of cationic liposomes composed of dipalmitoylphosphatidylcholine and dipalmityldimethylammonium bromide.

@article{Yokoyama2005MembranePO,
  title={Membrane properties of cationic liposomes composed of dipalmitoylphosphatidylcholine and dipalmityldimethylammonium bromide.},
  author={S. Yokoyama and A. Inagaki and T. Imura and T. Ohkubo and N. Tsubaki and H. Sakai and M. Abe},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2005},
  volume={44 4},
  pages={
          204-10
        }
}
Cationic liposomes composed of dipalmitoylphosphatidylcholine (DPPC) and dipalmityldimethylammmonium bromide (DPAB) were prepared by the Bangham method and the effect of DPAB on the membrane properties was examined in terms of liposomal shape, particle size, trapping efficiency, surface potential and dispersibility. The dispersibility of the mixed DPPC/DPAB liposomes (the mole fraction of DPAB (XDPAB)>==0.05) was excellent and the dispersibility was maintained for 6 months, since the zeta… Expand
9 Citations
Stearylamine Changes the Liposomal Shape from MLVs to LUVs
The shape of mixed dipalmitoylphosphatidylcholine (DPPC)/stearylamine (SA) liposomes prepared by the Bangham method was examined using freeze-fracture electron microscopy. The shape of the mixedExpand
Molecular packing and lateral interactions of distearoylphosphatidylcholine with dihexadecyldimethylammonium bromide in Langmuir monolayers and vesicles.
TLDR
The condensing effect and the increase of intermolecular attraction in mixed DSPC/DHDAB monolayers may be related to the stability enhancement of mixed vesicle composition as compared with the stability of pure component vesicles. Expand
Characterizing the structural transition of cationic DPPC liposomes from the approach of TEM, SAXS and AFM measurements.
TLDR
It seems that the shape transition of DPPC liposomes results from such electrostatic interactions as well as packing geometry of the two components, and the large-unilamellar vesicles are formed for reducing the inter- and intra-firm repulsive forces. Expand
Effect of chain length on physicochemical properties and cytotoxicity of cationic vesicles composed of phosphatidylcholines and dialkyldimethylammonium bromides.
TLDR
The morphological features (round shape, chromatin condensation and apoptosis bodies) and results of flow cytometry analysis confirmed the induction of apoptosis in HaCaT and SCC25 cells by cationic vesicles, suggesting that cytotoxicity is related to the zeta potential of the cationing vesicle. Expand
Charge boosting effect of cholesterol on cationic liposomes
Abstract Cationic liposomes that have been used as drug or gene delivery vehicles can be obtained by mixing cationic surfactants in phospholipid liposomes. Cytotoxicity of cationic molecules is oneExpand
Fabrication of positively charged catanionic vesicles from ion pair amphiphile with double-chained cationic surfactant
In this study, a pseudodouble-chained ion pair amphiphile, hexadecyltrimethylammonium-dodecylsulfate (HTMA-DS), was prepared from a mixture of cationic surfactant, hexadecyltrimethylammonium bromide,Expand
Nanoliposomes as a Platform for Delivery of Antimicrobials
The recent expansion of pharmaceutical nanotechnology (nanomedicines) and targeting strategies for antimicrobial delivery are highlighted and utilized in the applied fields of biomedicine,Expand
Direct measurement of surface charge distribution in phase separating supported lipid bilayers.
TLDR
The measured surface charge densities reveal that disordered domains formed by charged lipids are in fact not only impure, but also incorporate uncharged saturated lipids, which could present a limit for the formation of charged domains in lipid membranes. Expand
Functional liposomes in the cancer-targeted drug delivery
TLDR
These novel systems were found very promising and encouraging dosage forms for the treatment of different types of cancer by increasing efficiency and reducing the systemic toxicity due to the specific drug delivery and targeting. Expand

References

SHOWING 1-10 OF 21 REFERENCES
Preparation and physicochemical properties of various soybean lecithin liposomes using supercritical reverse phase evaporation method
Abstract Three kinds of soybean lecithin liposomes composed of phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), and phosphatidic acid (PA), were prepared by usingExpand
Preparation of liposomes containing Ceramide 3 and their membrane characteristics.
  • Imura, Sakai, +4 authors Abe
  • Chemistry, Medicine
  • Colloids and surfaces. B, Biointerfaces
  • 2001
TLDR
These phenomena were suggested to be related to the previously observed fact for the mixed DPPC/Ceramide 3 monolayers that Ceramide 3 interacts with DPPC in the liquid-expanded phase with consequent phase separation accompanied with domain formation. Expand
Formation and characterization of phosphatidylethanolamine/lysophosphatidylcholine mixed vesicles.
TLDR
The lipid aggregates formed by adding lysophosphatidylcholine (lysoPC) solution to phosphatidylethanolamine (PE) dispersion were proved to be a vesicle system judged from the negatively stained electron micrographs and the latency of calcein fluorescence. Expand
Spontaneous Vesicle Formation from Aqueous Solutions of Didodecyldimethylammonium Bromide and Sodium Dodecyl sulfate Mixtures
Spontaneous vesicle formation in the aqueous mixture of didodecyldimethylammonium bromide (DDAB) and sodium dodecyl sulfate (SDS) has been investigated with differential interference microscopy,Expand
DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery: zeta potential measurements and electron spin resonance spectra.
TLDR
ESR spectra showed that no major alteration took place after lipoplex formation and molecular packing remained substantially unchanged, and both zeta potential and ESR measurements were in favor of an external mode of packing of the lipoplexes. Expand
Development of a New Preparation Method of Liposomes Using Supercritical Carbon Dioxide
A new method, the supercritical reverse phase evaporation method, for the preparation of liposomes in one step using supercritical carbon dioxide without any organic solvent toxic to the human bodyExpand
Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation.
  • F. Szoka, D. Papahadjopoulos
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1978
TLDR
A substantial fraction of the aqueous phase is entrapped within the vesicles, encapsulating even large macromolecular assemblies with high efficiency, and has unique advantages for encapsulating valuable water-soluble materials such as drugs, proteins, nucleic acids, and other biochemical reagents. Expand
Diffusion of univalent ions across the lamellae of swollen phospholipids.
TLDR
It is found that as the surface charge of the lipid lamellae is increased, the amount of cation per μmle of lipid increases, and the phospholipid liquid crystalline structures appear to “bind” or “capture” cations. Expand
Correlation between structure and transfection efficiency: a study of DC-Chol--DOPE/DNA complexes.
TLDR
The results show that DC-Chol--DOPE/DNA lipoplexes have a columnar inverted hexagonal structure, which is not influenced by the cationic liposome/DNA charge ratio, and it seems that the lipoplex structures have not any influence on transfection efficiency and toxicity in the experimental system. Expand
Zeta potentials of gum arabic stabilised oil in water emulsions
Abstract The electrostatic contribution to the mechanism by which gum arabic stabilises oil in water has been investigated using laser Doppler electrophoresis. Electrophoretic mobilities of dExpand
...
1
2
3
...