Membrane properties, response to amines and to tetanic stimulation of hippocampal neurons in the genetically epileptic mutant mouse tottering

@article{Kostopoulos1988MembranePR,
  title={Membrane properties, response to amines and to tetanic stimulation of hippocampal neurons in the genetically epileptic mutant mouse tottering},
  author={George Kostopoulos and Caterina Psarropoulou and Helmut L. Haas},
  journal={Experimental Brain Research},
  year={1988},
  volume={72},
  pages={45-50}
}
SummaryThe petit-mal seizures of the “tottering” mutant mouse (tg) have been attributed to an exaggerated noradrenergic projection from locus coeruleus to the telencephalon (Noebels 1984). In order to investigate the possible epileptogenic mechanisms involved, we have compared hippocampal slices from epileptic (tg/tg) and phenotypically healthy (tg/+) mice. Resting potentials, action potentials and afterpotentials, membrane impedances and time constants were not significantly different in 11… CONTINUE READING

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