Membrane promotes tBID interaction with BCLXL

@article{GarcaSez2009MembranePT,
  title={Membrane promotes tBID interaction with BCLXL},
  author={Ana J. Garc{\'i}a-S{\'a}ez and Jonas Ries and Mar Orz{\'a}ez and Enr{\'i}que P{\'e}rez-Pay{\'a} and Petra Schwille},
  journal={Nature Structural &Molecular Biology},
  year={2009},
  volume={16},
  pages={1178-1185}
}
Two important questions on the molecular mechanism of the B cell CLL/lymphoma 2 (BCL2) proteins involve the interaction network between pro- and antiapoptotic members and the role of their translocation to the mitochondrial membrane during apoptosis. We used fluorescence correlation spectroscopy to quantify the molecular interactions of BH3-interacting domain death agonist (BID) and its truncated form tBID with the B cell lymphoma extra-large protein truncated at the C terminus (BCLXLΔCt) in… CONTINUE READING

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opposing activities that mediate cell death

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