Membrane potential-dependent binding of polysialic acid to lipid monolayers and bilayers

@inproceedings{Nowotarski2013MembranePB,
  title={Membrane potential-dependent binding of polysialic acid to lipid monolayers and bilayers},
  author={Krzysztof Nowotarski and Karolina Sapoń and Monika Kowalska and Tadeusz Janas and Teresa Janas},
  booktitle={Cellular & Molecular Biology Letters},
  year={2013}
}
Polysialic acids are linear polysaccharides composed of sialic acid monomers. These polyanionic chains are usually membrane-bound, and are expressed on the surfaces of neural, tumor and neuroinvasive bacterial cells. We used toluidine blue spectroscopy, the Langmuir monolayer technique and fluorescence spectroscopy to study the effects of membrane surface potential and transmembrane potential on the binding of polysialic acids to lipid bilayers and monolayers. Polysialic acid free in solution… CONTINUE READING
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