Membrane phosphatidylserine regulates surface charge and protein localization.

  title={Membrane phosphatidylserine regulates surface charge and protein localization.},
  author={Tony Yeung and Gary E. Gilbert and Jialan Shi and John R Silvius and Andras Kapus and Sergio Grinstein},
  volume={319 5860},
Electrostatic interactions with negatively charged membranes contribute to the subcellular targeting of proteins with polybasic clusters or cationic domains. Although the anionic phospholipid phosphatidylserine is comparatively abundant, its contribution to the surface charge of individual cellular membranes is unknown, partly because of the lack of reagents to analyze its distribution in intact cells. We developed a biosensor to study the subcellular distribution of phosphatidylserine and… CONTINUE READING
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