Membrane-perturbing domains of HIV type 1 glycoprotein 41.

  title={Membrane-perturbing domains of HIV type 1 glycoprotein 41.},
  author={Patrick W. Mobley and Rosemarie M. Pilpa and Charles Brown and Alan J. Waring and Larry M. Gordon},
  journal={AIDS research and human retroviruses},
  volume={17 4},
Structural and functional studies were performed to assess the membrane actions of peptides based on HIV-1 glycoprotein 41,000 (gp41). Previous site-directed mutagenesis of gp41 has shown that amino acid changes in either the N-terminal fusion or N-leucine zipper region depressed viral infection and syncytium formation, while modifications in the C-leucine zipper domain both increased and decreased HIV fusion. Here, synthetic peptides were prepared corresponding to the N-terminal fusion region… CONTINUE READING


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