Membrane-permeable Triphosphate Prodrugs of Nucleoside Analogues.

@article{Gollnest2016MembranepermeableTP,
  title={Membrane-permeable Triphosphate Prodrugs of Nucleoside Analogues.},
  author={Tristan Gollnest and Thiago Dinis de Oliveira and Anna K Rath and I. Hauber and D. Schols and J. Balzarini and C. Meier},
  journal={Angewandte Chemie},
  year={2016},
  volume={55 17},
  pages={
          5255-8
        }
}
The metabolic conversion of nucleoside analogues into their triphosphates often proceeds insufficiently. Rate-limitations can be at the mono-, but also at the di- and triphosphorylation steps. We developed a nucleoside triphosphate (NTP) delivery system (TriPPPro-approach). In this approach, NTPs are masked by two bioreversible units at the γ-phosphate. Using a procedure involving H-phosphonate chemistry, a series of derivatives bearing approved, as well as potentially antivirally active… Expand
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References

SHOWING 1-10 OF 30 REFERENCES
Nucleoside Diphosphate Prodrugs: Nonsymmetric DiPPro-Nucleotides.
  • 23
  • PDF
An improved method for the synthesis of nucleoside triphosphate analogues.
  • 35
...
1
2
3
...