Membrane-permeable Triphosphate Prodrugs of Nucleoside Analogues.

  title={Membrane-permeable Triphosphate Prodrugs of Nucleoside Analogues.},
  author={Tristan Gollnest and Thiago Dinis de Oliveira and Anna Katharina Rath and Ilona Hauber and Dominique Schols and Jan Balzarini and Chris Meier},
  journal={Angewandte Chemie},
  volume={55 17},
  • Tristan Gollnest, Thiago Dinis de Oliveira, +4 authors Chris Meier
  • Published in Angewandte Chemie 2016
  • Medicine, Chemistry
  • The metabolic conversion of nucleoside analogues into their triphosphates often proceeds insufficiently. Rate-limitations can be at the mono-, but also at the di- and triphosphorylation steps. We developed a nucleoside triphosphate (NTP) delivery system (TriPPPro-approach). In this approach, NTPs are masked by two bioreversible units at the γ-phosphate. Using a procedure involving H-phosphonate chemistry, a series of derivatives bearing approved, as well as potentially antivirally active… CONTINUE READING

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