Membrane permeability to macromolecules mediated by the membrane attack complex.

@article{Malinski1989MembranePT,
  title={Membrane permeability to macromolecules mediated by the membrane attack complex.},
  author={Justine A Malinski and Gary L. Nelsestuen},
  journal={Biochemistry},
  year={1989},
  volume={28 1},
  pages={61-70}
}
A simple and well-defined system of purified phospholipids and human complement proteins was used to study membrane permeability to macromolecules mediated by the membrane attack complex (MAC) of complement. Large unilamellar vesicles (LUVs) of phosphatidylcholine (PC) or phosphatidylserine (PS) containing trapped macromolecules [bovine pancreatic trypsin inhibitor (BPTI), thrombin, glucose-6-phosphate dehydrogenase (G6PD), and larger molecules] were used to monitor permeability. Membrane… CONTINUE READING