Membrane permeability of redox active metal chelators: an important element in reducing hydroxyl radical induced NAD+ depletion in neuronal cells.

@article{Jayasena2007MembranePO,
  title={Membrane permeability of redox active metal chelators: an important element in reducing hydroxyl radical induced NAD+ depletion in neuronal cells.},
  author={Tharusha Jayasena and R S Grant and N Keerthisinghe and I Solaja and George A. Smythe},
  journal={Neuroscience research},
  year={2007},
  volume={57 3},
  pages={454-61}
}
There is substantial evidence implicating increased production of the hydroxyl radical and oxidative stress in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). Significant amounts of hydroxyl radicals will be produced in the presence of hydrogen peroxide and redox active iron via Fenton chemistry. Increased iron levels within the cytoplasm of vulnerable neurons suggest that this may also be an important site of oxidative activity. We investigated the likelihood… CONTINUE READING