Membrane permeability of fructose-1,6-diphosphate in lipid vesicles and endothelial cells

@article{Ehringer2000MembranePO,
  title={Membrane permeability of fructose-1,6-diphosphate in lipid vesicles and endothelial cells},
  author={William D. Ehringer and Wenying Niu and Benjamin N. Chiang and Ou-Li Wang and Laura Gordon and Sufan Chien},
  journal={Molecular and Cellular Biochemistry},
  year={2000},
  volume={210},
  pages={35-45}
}
Fructose-1,6-diphosphate (FDP) is a glycolytic intermediate which has been used an intervention in various ischemic conditions for two decades. Yet whether FDP can enter the cell is under constant debate. In this study we examined membrane permeability of FDP in artificial membrane bilayers and in endothelial cells. To examine passive diffusion of FDP through the membrane bilayer, L-a-phosphatidylcholine from egg yolk (Egg PC) (10 mM) multi-lamellar vesicles were created containing different… CONTINUE READING
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