Membrane of Candida albicans as a target of berberine

  title={Membrane of Candida albicans as a target of berberine},
  author={N. Zori{\'c} and I. Kosalec and S. Tomic and Ivan Bobnjari{\'c} and M. Jug and Toni Vlaini{\'c} and J. Vlaini{\'c}},
  journal={BMC Complementary and Alternative Medicine},
  • N. Zorić, I. Kosalec, +4 authors J. Vlainić
  • Published 2017
  • Biology, Medicine
  • BMC Complementary and Alternative Medicine
  • BackgroundWe investigated the mechanisms of anti-Candida action of isoquinoline alkaloid berberine, active constituent of medically important plants of Barberry species.MethodsThe effects on membrane, morphological transition, synthesis of ergosterol and the consequent changes in membrane permeability have been studied. Polarization and lipid peroxidation level of the membrane following berberine treatment have been addressed.ResultsMinimal inhibitory concentration (MIC) of berberine against C… CONTINUE READING


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